Elucidating nuclear reprogramming mechanisms
The Minister of Education, Culture, Sports, Science and Technology authorized our undertaking of the human ES cell derivation.Our human ES cell derivation project is the second to receive a license throughout the nation.On this developmental time line, key transcription factors, such as Oct4, Sox2 or Nanog, have been revealed not only to regulate but also to functionally induce pluripotency.These early master regulators of development control developmental signalling pathways that affect the cell cycle, regulate gene expression, modulate the epigenetic state and repair DNA damage.
Gremlin enhances the determined path to cardiomyogenesis. Zhu W, Shiojima I, Ito Y, Li Z, Ikeda H, Yoshida M, Naito AT, Nishi J, Ueno H, Umezawa A, Minamino T, Nagai T, Kikuchi A, Asashima M, Komuro I. Nuclear reprogramming and the control of differentiation in mammalian embryos.
The ES cells produced by SCNT retained their self-renewal and pluripotent capabilities, contributing to all germ cell layers.