Each antidepressant produces approximately a 60% overall response rate (ie, at least a 50% reduction in symptoms as a result of treatment).However, some differences in the SSRIs efficacy exist.Low levels of serotonin and norepinephrine have not been proven to cause depression but it is widely believed that elevation of these chemicals is associated with improvement in mood in depressed people.All selective serotonin reuptake inhibitors have the same principal mechanism of action.Celexa (Citalopram) licensed indications: In January 2003, Prozac (fluoxetine) was approved by the FDA for the treatment of depression and OCD in children and adolescents who are 7 to 17 years of age.Zoloft (Sertraline) licensed indications: Clinical trials comparing one SSRI with another indicate that drugs in this class are equally efficacious.However, SSRIs differ in their potency and selectivity in inhibiting serotonin reuptake and many of them have important effects on other transporters and receptors.
The SSRIs differ in their licensed indications for non-depression disorders (which differ between countries).
This leads to differences among the SSRIs in their half-lives, clinical activity, side effects, and drug interactions.
Certain differences between SSRIs are clinically significant.
But other non-pharmaceutical things can have sedative effects, like a soothing cup of tea or a relaxing glass of wine.
The tryptophan in turkey is actually a natural sedative — that's why everyone is sleepy after Thanksgiving dinner!Nausea The most common side effect associated with use of SSRIs is nausea.